Immuno-modulatory Activity of Dushivishari Agada(Abstract)

Immuno-modulatory Activity of Dushivishari Agada, an Ayurveda preparation in Allergic asthma induced experimentally in wistar rats.

        Santosh  F. Patil1, S. K. Hiremath2 , Banappa Unger3 , Kalanghot P. Skandan

  1. Department of Agadatantra, KAHER’s Shri B. M. Kankanwadi Ayurveda Mahavidyalaya Belagavi , Karnataka India – 590003
  2. Department of Agadatantra, Taranath Government Ayurvedic Medical college. Bellary Karnataka, India – 533101
  3. I C M R – National Institute of Traditional Medicine Belagavi, Karnataka, India
  4. KAHER’s Shri B. M. Kankanwadi Ayurveda Mahavidyalaya, Belagavi, Karnataka, India – 590003

ADDRESS FOR CORRESPONDENCE:

Dr Santosh F Patil, Department of Agadatantra, KAHER’s Shri B. M. Kankanwadi Ayurveda Mahavidyalaya, Belagavi, Karnataka, India- 590003. Email : dr.santosh19@gmail.com

Financial support: None, Conflict of Interest: None

ABSTRACT.

Background: Asthma is chronic airway inflammatory disorder hallmarked with altered tracheo-bronchial response. WHO estimated three hundred million people suffer from Asthma all over the world and several medicines are available. In Ayurveda, the ancient system of Medicinal Science, this condition is well narrated and treatment offered is Dushivishari Agada (DVA) in powdered form.

Methodology: In this study we evaluated the effect of DVA in allergic asthma by experimentally inducing it in wistar rats. Animals were divided into four groups. Normal group (G I) was given orally normal saline for sensitization. In three experimental groups (G II,G III,G IV), asthma was induced by sensitizing with intra-peritoneal  Ovalbumin (OVA) and aluminium hydroxide and after 15 days they were challenged with OVA-PBS (Phosphate buffer solution) aerosols for 8 consecutive days. Animals in G II served as asthma control while G III and IV received DVA (250 mg) and Dexamethasone DXM (10mg/kg) respectively. In blood total and differential count, absolute eosinophil count (AEC), Serum IgE was done. Cellular count was done in Broncho-alveloar lavage fluid (BALF) and lungs underwent histological analysis.

Results DVA significantly reduced serum IgE (3.33 ± 1.08), AEC (145 ± 81.27) and inflammatory cells in BALF when compared to G II [Serum IgE (14.17± 1.16) and AEC (379.2 ± 206.4)] and was in comparison with G IV [Serum IgE (4.017± 0.68), AEC (50 ± 38.73)]

Conclusion DVA has shown immune-modulatory effect by bringing down inflammation in allergic bronchial asthma.

Keywords: Allergy, Asthma, Immuno-modulatory, Dushivishari agada

HOW TO CITE THIS ARTICLE: Patil S F, Hiremeth S K, Unger B, Skandan K P. Immuno – modulatory activity of Dushiishari agada an Ayurveda preparation in Allergic asthma induced experimentally in wistar rats. Indian J Ayurveda Res 2018;1:19-24