Immuno-modulatory activity of Rasayana Churna (A Polyherbal Ayurvedic formulation) in Charle’s Foster rats
Chaudhari Swapnil1 ,Verma Priyanka2,Galib R3 ,Nariya M4, Patgiri BJ 4,Pajapati PK3
1.Central Ayurveda Research Institute fpr Drug Development ,Kolkata 700091
2.Om Ayurveda and Panchakarma Hospital,Bhavnagar,Gujurat.
3.Dept of Rasashastra and Bhaishajya Kalpana ,All India Institute of Ayurveda,New Delhi,India 110076
4.IPGT &RA ,Gujarat Ayurved University ,Jamnagar,Gujarat 361008
ADDRESS FOR CORESSPONDENCE:
Dr R Galib ,Dept of Rasashastra and Bhaishajya Kalpana,All India Institute of Ayurveda,New Delhi,India-110076.
Background:Rasayana Churna is a poly-herbal formulation comprising fine powders of Guduchi (Tinospora cordifolia Linn.), Gokshura (Tribulus terrestris Linn.) and Amalaki (Emblica officinalis Linn.) in equal quantities. In Ayurveda, it is expected that the therapeutic efficacy of drug will be increased by levigating with its own juice or decoction. Kupeelu (Strychnos nux-vomica Linn.) is incorporated in this formulation since it is having analgesic, anti-inflammatory and adaptogenic properties. In current work, the immuno-modulatory activity of Rasayana Churna and Bhavita Rasayana Churna each mixed with Kupeelu was evaluated for humoral antibody formation and cell-mediated immunity in suitable experimental models.
Methods:Test drugs were administered orally to the albino rats at a dose of 540mg/kg body weight. Haemagglutination titre, body weight, hematological and histological observations were recorded to assess effects on humoral immunity. Cell-mediated immunity was assessed by immunological paw edema volume.
Results:Both the test drugs have minimal effects on SRBC induced humoral immune response. They did not modify the antibody titre values, hematological values and histo-pathological parameters. Both the drugs produced marked effect on cell mediated immunity response against triple antigen.
Conclusion: Rasayana Churna mixed with Kupeelu have more pronounced effect as compared to Bhavita Rasayana Churna mixed with Kupeelu in suppressing immunological edema.
KEY WORDS: Haemagglutination titre, Immune-modulatory activity, Rasayana churna, Strychnos nux-vomica
HOW TO CITE THIS ARTICLE: Chaudari S,Verma P,Galib R,Nariya M ,Patgiri BJ,Prajapati PK .Immuno-modulatory activity of Rasayana Churna (An Ayurvedic compound formulation) in wister albino rats .Indian J Ayurveda Res 2018;1:55-61
Financial Support and Sponsership :Nil
Conflicts of Interest:None